Spinal Anesthesia With Articaine and Lidocaine for Outpatient Surgery.

Spinal Anesthesia With Articaine and Lidocaine for Outpatient Surgery: A Double Blind Randomized Clinical Trial.

Status

Completed

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00247741

Enrollment

Registered

2005-11-02

Start date

2005-11-30

Completion date

2006-05-31

Last updated

2013-12-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Spinal Anesthesia

Keywords

spinal anesthesia, lidocaine, articaine, intrathecal

Brief summary

The purpose of this study is to compare two short-acting local anesthetics, articaine and lidocaine, for spinal anesthesia in day-case surgery. The onset time of the sensory- and motor block, recovery time until discharge and complications will be studied.

Detailed description

The ideal spinal anesthesia in day-case surgery is characterized by a short onset of sensory and motor blockade, and a rapid recovery after the operation. Short-acting local-anesthetics are used frequently in this setting. Lidocaine is one of the agents that is used most frequently. It has been associated with an increased incidence of Transient Neurological Symptoms (TNS). Articaine is another agent that is being used more often and is said to act faster and shorter than lidocaine. We will compare spinal anesthesia with lidocaine and articaine in a randomized double-blind clinical trial. Endpoint are: * onset of sensory and motor block * recovery from sensory and motor block * time to micturition * patient satisfaction * complications

Interventions

DRUGspinal administration of articaine

DRUGspinal administration of lidocaine

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Age \> 18 years * ASA I-III * Patients planned for a short surgical procedure on lower extremities or lower abdomen. * Procedure in day-case setting * Procedure under spinal anesthesia * Informed consent

Exclusion criteria

* Contra-indications spinal anesthesia * History of allergic reactions on amide-type local anesthetics * Pregnancy

Design outcomes

Primary

Measure	Time frame
Onset time (sec) of sensory and motor blockade (after administration of drug)	—
Recovery time (min) from sensory and motor blockade	—
Spread of sensory blockade (30 min after administration of drug, dermatomal level)	—

Secondary

Measure	Time frame
Hemodynamic stability (lowest systolic blood pressure, vasopressor therapy)	—
Complications	—
Patient satisfaction	—

Countries

Netherlands

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026