Renal Impairment After Cardiac Surgery
Conditions
Brief summary
The purpose of the project is to test whether or not the commonly used medication frusemide, given after heart surgery, and aiming to increase urinary output can have an effect on kidney function.
Detailed description
All patients will receive standard supportive care based on current established management practice of cardio-thoracic patients. The only difference in treatment will be the randomisation of patients to receive/not receive protocolised administration of frusemide targeting a urine output. There will be 2 groups of patients. The control group-which will receive frusemide bolus doses if required as determined by the surgeon/consultant physician. The frusemide infusion group-which will be monitored to achieve a trial specified hourly urine output target range of 1-2mls/kg/hour. In order to achieve this target the patient may need to receive a loading dose of frusemide and may also then require a frusemide infusion. The aim will be to maintain the urine output within the target range for the first 48 hours after cardiac surgery.
Interventions
DRUGFrusemide
Sponsors
Melbourne Health
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
All patients admitted for cardiac surgery will be assessed for eligibility. Participants will be approached for inclusion, from the pre-admission clinics and wards of the Cardiothoracic surgery unit. Potential participants will be identified by the daily review of planned cardiothoracic surgery schedule.
Exclusion criteria
1. Already in established dialysis dependent chronic renal failure. 2. Known allergy to frusemide 3. Age \< 18 years 4. Pregnant
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of increase in creatinine of 0.05 mmol/L or greater in the first 72 hours after cardiac surgery. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. The maximum change in serum creatinine from baseline value during the first 7 days of hospital stay. | — |
| 2. Incidence of renal failure requiring any form of renal replacement therapy. | — |
| 3. Duration of post-operative hospital and ICU stay. | — |
| 4. The maximum Sequential Organ Failure Assessment (SOFA) score in the first 7 days of hospital stay. | — |
Countries
Australia
Outcome results
None listed