Circadian Rhythm Sleep Disorder
Conditions
Keywords
circadian, advanced sleep phase, delayed sleep phase
Brief summary
The purpose of this study is to determine the properties of circadian rhythms and sleep propensity in familial advanced and delayed sleep phase syndrome (DSPS).
Detailed description
BACKGROUND: Tremendous progress in the past few years has led to the identification of several circadian clock genes. This now makes it possible to determine how alterations of human circadian clock genes and their expression could lead to differences in circadian and sleep/wake cycle phenotypes. Of particular interest for understanding genetics of the human circadian system are individuals with sleep phase disorders, such as DSPS and advanced sleep phase syndrome (ASPS), because recent studies indicate a genetic basis for these disorders. While it is assumed that both ASPS and DSPS are disorders of circadian timing, little is known about how the circadian clock system, or its interaction with sleep processes, are affected in these individuals. DESIGN NARRATIVE: Participants will complete questionnaires and actigraphy to determine sleep patterns and quality.
Interventions
None listed
Sponsors
National Heart, Lung, and Blood Institute (NHLBI)
Northwestern University
Study design
Observational model
OTHER
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
for ASPS Participants: * Morning type score on the Horne-Ostberg questionnaire * Advanced melatonin onset Inclusion Criteria for DSPS Participants: * Evening type score on the Horne-Ostberg questionnaire * Delayed melatonin onset Inclusion Criteria for Controls: * A stable sleep/wake pattern with a normal phase relationship to the environment and no history of sleep disorders
Exclusion criteria
for all subjects: * Sleep disorder, other than DSPS or ASPS, as assessed by the Pittsburgh Sleep Quality Index and/or by polysomnogram * History of cognitive or other neurological disorders * History of Diagnostic and Statistical Manual-IV criteria for any major psychiatric disorder, alcohol or substance abuse * Abnormal mood as assessed by the Hamilton Depression Scale * History of, or concurrent, unstable or serious medical illness * Current use of psychoactive medications, including antidepressants, anxiolytics, neuroleptics, anticonvulsants, hypnotics, and stimulant medications * Shift work * Having a daily caffeine intake greater than 4 cups per day * Smoking * Travel across more than 2 time zones within 90 days of the study * Pregnancy or the desire to become pregnant during the study period
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Sleep | 1 night | Assessment of sleep parameters |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Circadian Timing | 3 days | Assessment of circadian activity profiles |
Countries
United States
Outcome results
None listed