Adenoma, Colon Cancer, Polyp
Conditions
Keywords
Colonoscopy, Chromoscopy, Prevention
Brief summary
The proposed research aims to determine the prevalence, size, shape and histology of flat colorectal neoplasms in a cohort of asymptomatic, average-risk individuals presenting for screening colonoscopy. Patients will be randomized to either conventional colonoscopy or chromocolonoscopy, where the entire colon will be sprayed with indigocarmine dye and examined in the usual manner. The primary outcome will be the total number of adenomas detected, with special attention to the subgroup of flat and depressed lesions. To promote the generalizability of the results, neoplasms will be described according to standard Western and Japanese classification schemes.
Interventions
PROCEDUREChromocolonoscopy
Indigocarmine dye applied to entire colon to highlight mucosal detail and enhance detection of flat lesions.
Sponsors
American College of Gastroenterology
Stony Brook University
University of Chicago
Indiana University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
50 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Patients undergoing screening colonoscopy
Exclusion criteria
* Age \< 50 * Prior colon resection * Inflammatory bowel disease * Prior colonoscopy or sigmoidoscopy * More than one first-degree relative with colon cancer
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Prevalence of adenomas detected by chromocolonoscopy versus standard colonoscopy. | Cross-sectional prevalence of adenomas between the 2 study groups |
Countries
United States
Outcome results
None listed