Obesity
Conditions
Brief summary
The purpose of the study is to evaluate if supplementation with vitamin D in doses of 20.000IU per week and 40.000 IU per week will result in weight loss in obese subjects as compared to placebo during 1 year.
Detailed description
We will include 450 obese subjects that will be devided in 3 groups: 40.000IU cholecalciferol per week, 20.000 IU cholecalciferol per week, and placebo. All subjects will be given 500 mg calcium per day. There will be visits every tird month. In addition to weight reduction, we will also evaluate the calcium metabolism (blood test and urin samples), insulin sensitivity, muscle strenght, blood pressure and depression.
Interventions
DRUGCholecalciferol
Sponsors
University of Tromso
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE
Eligibility
Sex/Gender
ALL
Age
21 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* BMI 30 - 40 * serum calcium \< 2.55 mmol/L
Exclusion criteria
* serious diseases * reduced kidney function * renal stone disease * using psychopharmaca * using drugs for weight reduction
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Body Weight | — |
| Body composition | — |
| Measures of calcium metabolism | — |
| Insulin sensitivity | — |
| Muscle strength | — |
| Depression score | — |
| Blood pressure | — |
Countries
Norway
Outcome results
None listed