A Study To Investigate Markers Of Inflammation In Rheumatoid Arthritis

An Enabling Study to Investigate the Correlation of Biomarkers of the Activity of Inducible Nitric Oxide Synthase (iNOS) With Disease Activity and Treatment Response in Patients With Rheumatoid Arthritis(RA)

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00242853

Enrollment

Registered

2005-10-21

Start date

2004-10-31

Completion date

Unknown

Last updated

2008-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis, Rheumatoid Arthritis

Keywords

iNOS, Rheumatoid arthritis, Exhaled NO

Brief summary

This study is being conducted to validate various biomarkers in patients with RA with varying levels of disease severity. Subjects with a diagnosis of rheumatoid arthritis (RA) will be included as controls. The sudy will measure the baseline levels and the intra- and inter-subject variability of exhaled nitric oxide (NO) in patients with inactive/mild and moderate/severe RA on stable therapy or during a course glucocorticoids. In addition exhaled NO levels will be correlated with intra-articular inflammation (power Doppler ultrasonography) as well as markers of systemic inflammation (CRP, ESR).

Interventions

PROCEDUREPower doppler ultrasonography

PROCEDUREHigh frequency ultrasonography

PROCEDUREExhaled nitric oxide assessment

Study design

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Inclusion criteria

* Diagnosis of rheumatoid or osteo-arthritis. * Weight greater than 45kg (females) or 50kg (males) but not overweight. * Non-smokers. * Taking stable anti-inflammatory medication for Rheumatoid Arthritis (RA) or Osteoarthritis (OA) for at least 8 weeks.

Exclusion criteria

* Taking regular doses of glucocorticoid medication (greater than 5mg/day). * Currently taking biological treatment for RA. * Recent participation in another clinical trial.

Countries

United Kingdom

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026