Anesthesia
Conditions
Keywords
general anesthesia, hyperventilation, carbon dioxide, isocapnic hyperponea
Brief summary
The twilight phase between being asleep and awake during recovery from anesthesia is a precarious time fraught with risks to the post-operative patient. Hyperventilation accelerates the elimination of inhaled anesthetics but reduces their CO2 blood concentrations which delays their resumption of spontaneous breathing. We previously showed that our method of hyperventilation without affecting the CO2 concentration--which we call IH--accelerates the rate of emergence from anesthesia with isoflurane. In this study we will study the effect of IH on the rate of emergence from Sevoflurane anesthesia.
Interventions
PROCEDUREIsocapnic Hyperponea
Sponsors
University Health Network, Toronto
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
1. Elective gynecological procedure 2. ASA I-III 3. Age 18-80 years 4. Signed informed consent
Exclusion criteria
1. ASA IV 2. Patients with contra-indications to Sevoflurane anesthesia or other anesthetics included in the protocol 3. Active smoking, asthma or other history of hyper-reactive airway disease 4. History of chronic obstructive lung disease limiting exercise 5. History of angina, previous myocardial infarction, valvular heart disease, or heart surgery 6. Presence of heart murmurs or neck bruits 7. ECT abnormalities including atrial fibrillation, prolonged P-R interval, prolonged Q-T interval, presence of Q waves in inferior, anterior or lateral leads, criteria for left ventricular hypertrophy, T-wave abnormalities, 8. History of difficult airway access 9. Pulmonary hypertension and/or right ventricle dysfunction 10. History of bulous emphysema, and/or spontaneous pneumothorax 11. History of alcohol or drugs abuse 12. Known history of psychiatric illness and/or medications 13. Patients that required postoperative mechanical ventilation for any reason
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to recovery from anesthesia as indicated by time to extubation and rate of change of BIS score | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of recovery in the recovery room as indicated by the level of consciousness, incidence of nausea, vomiting, shivering and other phenomena occuring during recovery | — |
Countries
Canada
Outcome results
None listed