Transplant
Conditions
Keywords
liver transplant, HHV-6, HHV-7, Human Herpesvirus-6, Human Herpesvirus-7
Brief summary
Human herpesvirus-6 (HHV-6) and -7 (HHV-7) infections are common after transplantation. Such infections may predispose transplant patients to other infections, contribute to a recurrence of hepatitis C virus, and affect rejection and function of the transplanted liver. Given the significant clinical impact of these viruses, routine laboratory monitoring may be beneficial by identifying patients who have persistent or high levels of infection. In these patients, immunosuppressive medications could be adjusted, or antiviral medications administered. There are currently no randomized trials that address this important question. This prospective, randomized trial will analyze whether routine laboratory monitoring for HHV-6 and -7 is clinically useful, and whether it would improve overall outcomes in transplant recipients.
Interventions
PROCEDUREMonitoring - blood samples drawn to test for HHV-6 and HHV-7
Sponsors
The Physicians' Services Incorporated Foundation
University Health Network, Toronto
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Male or female patients who fulfill the following criteria are eligible for inclusion: * Recipients of a liver transplant * Able to give written informed consent * Are willing and able to comply with the protocol * Age \>= 18 years
Exclusion criteria
The following patients are not eligible for inclusion in the study: * Patients unwilling or unable to give informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Adverse clinic events due to direct or indirect effects. | — |
Countries
Canada
Outcome results
None listed