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Effectiveness of Atypical Versus Conventional Antipsychotics in Treating Schizophrenia

Effectiveness of Atypical Vs Conventional Antipsychotics

Status
Completed
Phases
Phase 4
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT00237861
Enrollment
Unknown
Registered
2005-10-12
Start date
Unknown
Completion date
Unknown
Last updated
2014-06-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Schizophrenia

Brief summary

This study will compare the effectiveness of newer atypical antipsychotics versus older conventional antipsychotics in treating schizophrenia.

Detailed description

At seven participating hospitals, acutely exacerbated patients with schizophrenia were randomly assigned to treatment with antipsychotic from the atypical class vs antipsychotic from the conventional class. Medication choice within class, dose, concomitant medications, and other prescribing decisions were left to the community prescriber. Patients were followed for one year after discharge.

Interventions

DRUGrisperidone
DRUGolanzapine
DRUGquetiapine

Sponsors

National Institute of Mental Health (NIMH)
CollaboratorNIH
Yale University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE

Eligibility

Sex/Gender
ALL
Healthy volunteers
No

Inclusion criteria

* hospitalized for schizophrenia

Exclusion criteria

* none

Design outcomes

Primary

MeasureTime frame
PANSS—
Retention.—

Secondary

MeasureTime frame
EPS, TD.—

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026