Psoriasis Vulgaris
Conditions
Keywords
topical therapy, Psoriasis Plaque Test
Brief summary
The purpose of this study is to evaluate the efficacy of the topical therapies Protopic and Advantan as well as their combination against placebo in a Psoriasis Plaque Test
Detailed description
daily psoriasis plaque tests for two weeks and optical coherence tomography (OCT) and 20-MHz-ultrasound on day 0 and day 11, 10 days post end of treatment and 20 days post end of treatment
Interventions
Sponsors
Technische Universität Dresden
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients older than 18 Years * Negative urine pregnancy test * Written informed consent * Good compliance
Exclusion criteria
* Patients less than 18 years * Pregnant patients * Patients with renal insufficiency, liver diseases * Patients who received systemic antipsoriatic treatment or UV treatment less than 4 weeks prior to study * Patients who used topical antipsoriatics within two weeks prior to study * Immunosuppressed Patients
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| sum score of psoriasis plaque tests on day 11 | — |
Secondary
| Measure | Time frame |
|---|---|
| 20-MHz-ultrasound and OCT on day 11 | — |
Countries
Germany
Outcome results
None listed