Irritable Bowel Syndrome
Conditions
Keywords
residents of Walkerton ontario at outbreak
Brief summary
Acute Bacterial dysentery leads to chronic symptoms of disturbed bowel habit in a minority of individuals. This condition known as post infectious irritable bowel syndrome (PI-IBS) remains poorly understood. This could allow material in the bowel to reach deeper tissues of the bowel wall leading to inflammation and changes in muscle and nerve function. This is also early evidence that genetic programming of people with PI-IBS prevents them from turning off inflammation once it begins. Literature suggests that IBS may develop at greater rates in individuals with pro-inflammatory genotype and that these individuals may be at increased risk of inflammatory bowel diseases (IBD).
Detailed description
This research will study chronic gastrointestinal problems in the residents of Walkerton, Ontario region. Determine whether acute bacterial infection is a risk factor for development of inflammatory bowel disease using the population of Walkerton as a cohort. We hypothesize that exposure to bacterial infection leads to development of post infectious irritable bowel syndrome which is associated with an increase in intestinal permeability and immune activation with low grade intestinal inflammation and that this sequence of events will trigger inflammatory bowel disease in genetically susceptible individuals
Interventions
None listed
Sponsors
McMaster University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
16 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Participants must be residents of the Walkerton, Ontario region at the time of Outbreak who consented to the study
Exclusion criteria
* Non residents of Walkerton Ontario at the time of outbreak
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of Participants With Post Infectious Irritable Bowel Syndrome | 8 years |
Countries
Canada
Participant flow
Recruitment details
Residents of Walkerton in may 2000
Pre-assignment details
Age less than 16, non-residents of walkerton, premorbid Inflammatory Bowel disease(IBD) /Irritable bowel syndrome(IBS)
Participants by arm
| Arm | Count |
|---|---|
| Unexposed to Gastroenteritis | 1,575 |
| Exposed to Gastroenteritis | 2,986 |
| Total | 4,561 |
Withdrawals & dropouts
| Period | Reason | FG000 | FG001 |
|---|---|---|---|
| Overall Study | Lost to Follow-up | 746 | 1,400 |
Baseline characteristics
| Characteristic | Exposed to Gastroenteritis | Unexposed to Gastroenteritis | Total |
|---|---|---|---|
| Age, Categorical <=18 years | 907 Participants | 471 Participants | 1378.0 Participants |
| Age, Categorical >=65 years | 269 Participants | 199 Participants | 468.0 Participants |
| Age, Categorical Between 18 and 65 years | 1810 Participants | 905 Participants | 2715.0 Participants |
| Age Continuous | 34.97 years STANDARD_DEVIATION 21.61 | 36.96 years STANDARD_DEVIATION 22.76 | 35.66 years STANDARD_DEVIATION 22.03 |
| Region of Enrollment Canada | 2986 participants | 1575 participants | 4561.0 participants |
| Sex: Female, Male Female | 1665 Participants | 892 Participants | 2557.0 Participants |
| Sex: Female, Male Male | 1321 Participants | 683 Participants | 2004.0 Participants |
Outcome results
Primary
Number of Participants With Post Infectious Irritable Bowel Syndrome
Time frame: 8 years
| Arm | Measure | Value (NUMBER) |
|---|---|---|
| Unexposed to Gastroenteritis | Number of Participants With Post Infectious Irritable Bowel Syndrome | 23 participants |
| Exposed to Gastroenteritis | Number of Participants With Post Infectious Irritable Bowel Syndrome | 114 participants |