Pancreatic Cancer
Conditions
Brief summary
The purpose of the trial is to test the efficacy of combining conventional chemoradiotherapy with radiosurgery for locally advanced pancreas cancer.
Detailed description
The purpose of the trial is to test the efficacy of treating locally advanced pancreatic cancer with 5FU and concurrent conventional radiotherapy followed by precisely administered single fraction of high-energy radiation using a radiosurgical technique.
Interventions
DEVICEStereotactic Radiosurgery (Cyberknife)
Sponsors
Stanford University
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
- Pancreatic tumors not to exceed 7.5 cm. * Histologically confirmed malignancies of the pancreas, (ampulla of Vater or periampullary duodenum, tumors may be included when the head of pancreas is secondarily involved and unresectable criteria are met). * Unresectable by CT criteria or unresectable at exploratory laparotomy or laparoscopy. CT criteria for unresectability include encasement of the superior mesenteric vein (SMV), portal vein (PV) or invasion of the celiac artery or superior mesenteric artery (SMA). * Patients with metastatic disease may be treated if they are symptomatic from the primary tumor. * Eastern Clinical Oncology Group performance status 0, 1 or 2.
Exclusion criteria
Chemotherapy within 1 month of registration.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Efficacy of Conventional Chemoradiotherapy Followed by Stereotactic Radiosurgery | — |
Countries
United States
Outcome results
None listed