PiCCO Guided Therapy in Liver Cirrhosis

Optimized Therapy of Decompensated Liver Cirrhosis by Hemodynamic Monitoring Using the PiCCO System

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00232427

Enrollment

Registered

2005-10-04

Start date

2005-08-31

Completion date

2007-08-31

Last updated

2007-10-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Liver Cirrhosis

Keywords

Liver cirrhosis, Hemodynamics, Fluid balance

Brief summary

Prospective comparison of standard therapy in liver cirrhosis versus standard therapy plus intensified hemodynamic monitoring using the PiCCO system.

Detailed description

Patients presenting with advanced liver cirrhosis will receive either standard treatment or standard treatment plus hemodynamic monitoring with the PiCCO device. Fluids and vasoacitve drugs will be administered according to the measurements over a period of 5 days.

Interventions

PROCEDUREHemodynamic monitoring system PiCCO

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* Liver cirrhosis Child-Pugh-Score \> 7 * Ascites \> 500 ml

Exclusion criteria

* Coronary heart disease * Apoplexia \< 6 months ago * Vasculitis * Thrombosis * Arterial occlusive disease \> stadium II

Design outcomes

Primary

Measure	Time frame
Survival	—

Secondary

Measure	Time frame
Renal complications	—
Length of intensive care	—
Change in APACHE II	—

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026