Gastroesophageal Reflux
Conditions
Keywords
GORD - Oesophageal sensitivity- Oesophageal permeability
Brief summary
This study aims to characterize the permeability as well as some protein involved in the cell junction in the oesophageal epithelium in patients with GORD symptoms. In addition these patients will be characterized for their reflux especially by pH-impedancemetry, Bilitec and oesophageal acid perfusion test. Correlations between the characteristics of the reflux and the biological results will be calculated.
Detailed description
This study aims to characterize the permeability as well as some protein involved in the cell junction in the oesophageal epithelium in patients with GORD symptoms. In addition these patients will be characterized for their reflux especially by pH-impedancemetry, Bilitec and oesophageal acid perfusion test. Correlations between the characteristics of the reflux and the biological results will be calculated.
Interventions
None listed
Sponsors
Nantes University Hospital
Study design
Observational model
DEFINED_POPULATION
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
Main inclusion criteria : * Digestive symptoms suggestive of GORD (heartburn, regurgitation, epigastric pain), or dyspeptic syndrome (nausea, belch, bloating, epigastric discomfort). * Need of upper GI endoscopy and pH monitoring. * Normal propagation of oesophageal persitaltic waves (manometry \< 6 months). * Age 18 -70 yrs * Signed informed consent * Normal coagulation
Exclusion criteria
* Barrett's oesophagus * Previous oesophageal bleeding * Need of NSAID treatment. * Previous sus mesocolic surgery * Alcool consumption \> 40g/d, smoking \> 10 cig/j * Pregnancy or lack of contraceptive disposal, breast feeding. * Allergy to Xylocaïne
Countries
France
Contacts
Primary ContactStanislas Bruley Des Varannes, MD
Outcome results
None listed