Prostatic Neoplasms
Conditions
Brief summary
This is a pilot study of 50 patients to establish whether there is a potential role for MRI perfusion in the detection of locally recurrent or persistent prostate carcinoma after previous treatment with radiotherapy. All subjects will be patients who have had localised prostate cancer treated with radiotherapy and have already agreed to undergo a biopsy of the prostate to look at local control within the prostate as part of their management. The objective of the study is to establish whether there is a relationship between recurrent or persistent disease within the prostate and increased perfusion on MRI at these sites.
Interventions
DEVICEMRI
Sponsors
Princess Margaret Hospital, Canada
University Health Network, Toronto
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Previously have had radical radiotherapy for localised prostate cancer * Due to undergo routine post-treatment prostatic biopsies * Suitable for MRI scan * Adequate renal function * No previous reaction to gadolinium * Able to give informed consent * No recent prostate biopsy within 6 weeks of enrolment * Performance status (Eastern Cooperative Oncology Group \[ECOG\]) 0 or 1
Exclusion criteria
* Not suitable for MRI scan * Previous reaction to gadolinium * Impaired renal function * Inability to give informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To determine whether there may be a role for MRI perfusion in the detection of recurrent or persistent prostatic cancer after previous radiotherapy | — |
Countries
Canada
Outcome results
None listed