Effect of APC and Epo on the Inflammatory Response During Sepsis

Effect of Activated Protein C and Erythropoietin on the Microvascular Inflammatory Response During Severe Sepsis.

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00229034

Enrollment

Registered

2005-09-29

Start date

2005-09-30

Completion date

2011-09-30

Last updated

2017-08-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sepsis, Systemic Inflammation

Keywords

Systemic Inflammation, Microvascular Perfusion, Septic Shock

Brief summary

An observational study to determine the effect of APC and Epo in reducing the systemic inflammatory response during severe sepsis.

Detailed description

An observational study to determine the effect of APC and Epo in reducing the systemic inflammatory response during severe sepsis. Patients already prescribed either drug will be enrolled. The microcirculation of the sublingual vascular bed will be observed with a microscope to detect the alterations in the inflammatory response.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* patients in the ICU in severe septic shock undergoing APC and/or Epo treatment

Exclusion criteria

* any severe comorbid conditions

Countries

Canada

Outcome results