The Effect of Aerobic Exercise on Learning After Stroke

Effect of Cardiovascular Fitness on Motor Learning and Executive Function in Individuals After Stroke

Status

Completed

Phases

Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00228306

Enrollment

Registered

2005-09-28

Start date

2005-09-30

Completion date

2009-12-31

Last updated

2012-05-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stroke

Brief summary

Determine if attaining aerobic fitness is beneficial in producing cortical neuroplasticity in individuals with chronic stroke.

Detailed description

Crossover clinical trial. Experimental group undergoes 3x/wk/6 months of aerobic conditioning. Control group performs usual daily activities. All participants will be assessed with cognitive and motor behavioral testing at baseline, 3, 6, 9 and 12 months.

Interventions

BEHAVIORALRehabilitation exercise

Rehab therapy is delivered for 8 weeks.

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to 85 Years

Healthy volunteers

Inclusion criteria

* Single ischemic stroke occuring 6-72 months prior * Fugl-Meyer score (upper + lower extremity) 45 or greater * Mini mental status score of \>23 * approval of the subject's medical doctor

Exclusion criteria

* already performing \>20 min of cardiovascular exercise 3x/wk or more * alcohol consumption of \>2 oz. liquor, 8 oz. wine or 24 oz beer/day * cardiac history of unstable angina, recent myocardia infarction within the last 3 months, congestive heart failure, significant valve dysfunction * medical history of recent hospitalization (\> 3 months) for medical illness * symptomatic peripheral arterial occlusive disease * orthopedic or chronic pain conditions restricting exercise * pulmonary or renal failure * active cancer * unstable hypertension (\>160/100 mmHg) * diabetes mellitus (fasting glucose \> 180 NG./dk, HgA1C \> 10%) that is unable to be controlled \< month * receptive or expressive aphasia as indicated on MMSE * multiple strokes or other neuromuscular conditions * major depression that is untreated using the Beck depression inventory

Design outcomes

Primary

Measure	Time frame
Motor learning behavioral measures; executive function behavioral measures.	Baseline, 8 weeks, 12 weeks

Secondary

Measure	Time frame
Peak V02 and other aerobic capacity measures. Physical disability measures.	Baseline, 8 weeks, 12 weeks

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026