Quantifying Nitrous Oxide Effect on Depth of Anaesthesia Using Theoretically Based Time Series Modelling

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00226837

Enrollment

Registered

2005-09-27

Start date

2004-08-31

Completion date

2005-08-31

Last updated

2009-02-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Depth of Anaesthesia

Brief summary

Our hypothesis is that a new method of depth of anaesthesia monitoring, using theoretically based time series modelling will result in improved ability to determine nitrous oxide anaesthetic effect

Detailed description

We randomised patients to 0% 33% or 66% nitrous oxide during sevoflurane induction and measured anesthetic endpoints.

Interventions

DRUGNitrous oxide

nitrous oxide by inhalation during induction

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

DIAGNOSTIC

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Aged 18 years or older * Presenting for surgery under general anaesthesia

Exclusion criteria

* Poor English language comprehension * Risk of reflux * Epilepsy or other EEG abnormality

Design outcomes

Primary

Measure	Time frame
EEG index value during three concentrations of nitrous oxide	During induction of anaesthesia

Countries

Australia

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026