Neuromuscular Blockade
Conditions
Brief summary
The purpose of this study is to examine the precision, bias and limits of agreement when monitoring the neuromuscular block with acceleromyography with and without preload and compare the method to the gold standard, mechanomyography.
Interventions
DEVICEHand Adapter (Organon, Oss, the Netherlands)
Randomization of acceleromyography with or without Hand Adapter to dominant or non-dominant arm. Contralateral neuromuscular transmission is measured with mechanomyography (The gold standard of neuromuscular monitoring)
DEVICEPlacebo
placebo
Sponsors
Rigshospitalet, Denmark
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* ASA I-III * General anesthesia \> 1 hour * Surgery under supine position with possibility of monitoring the neuromuscular block in both arms (thumbs) * Written informed content
Exclusion criteria
* Neuromuscular disorders, hepatic and renal dysfunction * Medication expected to interfere with the neuromuscular blocking agent * Allergy to any medication used during anesthesia * Body weight less or exceeding 20% of the ideal body weight * Pregnancy or breastfeeding
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The precision of acceleromyography with and without preload during recovery | — |
Secondary
| Measure | Time frame |
|---|---|
| All the following outcomes obtained with AMG with and without preload are compared to MMG. Furthermore the responses are compared when the AMG-values are normalized: | — |
| Bias og limits of agreement between control TOF | — |
| Onset time | — |
| Time to reappearance of T1, T2, T3 and T4 | — |
| Twitch height of T1 at reappearance of T1, T2, T3 and T4 | — |
| Bias and limits of agreement for acceleromyography (AMG) with and without preload compared to mechanomyography (MMG) during recovery | — |
| Interval 25-75% | — |
| Time to TOF-ratio = 0.9 and 1.0 | — |
| Time to final T1 | — |
| Time to final TOF ratio | — |
| Time to T1=25% | — |
Countries
Denmark
Outcome results
None listed