KETOR: Effects of Peri Operative Administration of Ketamine on Long Term Post Thoracotomy Pain

Effects of Peri Operative Administration of Ketamine on Long Term Post Thoracotomy Pain

Status

Completed

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00224588

Enrollment

Registered

2005-09-23

Start date

2003-01-31

Completion date

2005-05-31

Last updated

2006-04-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Post Thoracotomy Pain, Ketamine, Neuralgia, Pain, Thoracotomy

Keywords

Ketamine, Chronic post thoracotomy pain, NMDA, Post operative

Brief summary

We assessed the effects of the N Methyl aspartate receptor antagonist Ketamine on long-term post thoracotomy pain. We hypothesized that ketamine could prevent supersensitization of the central nervous system involved in this chronic neuropathic pain.

Detailed description

In this clinical, randomized prospective study, peri operative administration of ketamine was compared to placebo on long term post thoracotomy pain after a 2 months follow up period.

Interventions

DRUGKetamine (or placebo : isotonic saline solution)

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE

Eligibility

Sex/Gender

ALL

Age

80 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients eligible for thoracotomy or pneumectomy

Exclusion criteria

Design outcomes

Primary

Measure	Time frame
Long term (2 months) post thoracotomy pain was assessed using a french equivalent of the Mc Gill Pain score and pain area measurements in both groups	—

Secondary

Measure	Time frame
Analogic pain scores at rest and after coughing	—

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026