Chronic Renal Insufficiency, Contrast Media Exposition, Serum Creatinine Concentration
Conditions
Keywords
prophylaxis, contrast-induced nephropathy, mesna, acute renal failure
Brief summary
The purpose of this study is to determine wether Mesna could prevent contrast-induced nephropathy
Detailed description
Contrast-induced nephropathy remains a common complication of radiographic precedures. Pretreatment with Mesna (Sodium 2-mercaptoethane sulfonate) in combination with sodium chloride is more protective than sodium chloride alone in animal models of acute renal failure. The aim of this study is therefore to determine laboratory and clinical benefit of MESNA, as an adjunct to saline hydration, in patients with known renal impairment receiving contrast media.
Interventions
DRUGsodium 2-mercaptoethane sulfonate
Sponsors
University of Ulm
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* stable chronic renal insufficiency * serum creatinine concentration \> 1,5 mg/dl
Exclusion criteria
* Dialyzed patients * patients with acute renal failure * received iodinated contrast media within 7 days before study entry * known allery to Mesna, pregnancy, and administration of dopamine, mannitol or N-acetylcysteine
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Contrast-agent associated nephrotoxicity was defined as an increase in serum creatinine concentration >0.5 mg/dl (44 umol/l) of the baseline value 48 h after administration of the contrast media. | — |
Secondary
| Measure | Time frame |
|---|---|
| Need for dialysis after the administration of contrast media. | — |
Countries
Germany
Outcome results
None listed