Chronic Apical Periodontitis of Pulpal Origin
Conditions
Keywords
pain
Brief summary
This clinical trial evaluates the role of cytokines in patients needing root canal treatment with diagnosis of necrotic pulp and chronic apical periodontitis
Detailed description
This study evaluates whether periradicular exudate concentrations of cytokines differ in patients experiencing pain and mechanical allodynia due to pulpal necrosis with an acute exacerbation of a chronic apical periodontitis, as compared to patients with pulpal necrosis with chronic apical periodontitis, but no pain or mechanical allodynia
Interventions
None listed
Sponsors
National Institutes of Health (NIH)
National Institute of Dental and Craniofacial Research (NIDCR)
The University of Texas Health Science Center at San Antonio
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
16 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
1. Patient must be at least 16 years of age. 2. Clinical indication for Non-Surgical Root Canal Therapy (NSRCT). 3. 1st or 2nd maxillary or mandibular molar 4. Diagnosis must be Chronic Apical Periodontitis (CAP) with or without symptoms. 5. Intact, mature apices. 6. ASA I or II
Exclusion criteria
1. Failure to meet any of the above 2. Previous NSRCT 3. Previous pulpotomy or pulpectomy 4. Suppurative apical periodontitis 5. Patients taking medications which can affect their pain rating or medications which effect their immune system ( such as glucocorticoids)
Countries
United States
Outcome results
None listed