Concentration of Plant Sterols in Serum and Aortic Valve Cusps

Concentrations of Plant Sterols in Serum and Aortic Valve Cusps: a Prospectiv Observational Study

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00222950

Enrollment

100

Registered

2005-09-22

Start date

2003-09-30

Completion date

2005-09-30

Last updated

2005-09-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aortic Valve Stenosis

Keywords

plant sterols, serum, aortic valve cusps

Brief summary

This study investigates the effect of margarines supplemented with plant sterol esters on serum and cardiovascular tissue concentrations of plant sterols. We assume that consumption of margarine supplemented with plant sterol esters increases serum and cardiovascular tissue concentrations of plant sterols (sitosterol; campesterol).

Detailed description

The role of plant sterols in cardiovascular diseases is controversially debated. There is an increasing body of evidence that indicates that increased plant sterol serum concentrations are correlated with an increased cardiovascular risk. Functional foods such as margarines supplemented with plant sterol esters are advertised to patients with hypercholesterolemia. Numerous studies show that margarines supplemented with plant sterol esters reduce serum cholesterol concentrations significantly. However, there are no studies available investigating relevant clinical endpoints. Nor are there any studies availabe investigating the effect of the consumption of margarines supplemented with plant sterol esters on serum and cardiovascular tissue concentrations. This study is done to investigate the effect of margarines supplemented with plant sterol esters on serum and cardiovascular tissue concentrations.

Interventions

None listed

Study design

Observational model

DEFINED_POPULATION

Time perspective

OTHER

Eligibility

Sex/Gender

ALL

Age

0 Years to No maximum

Healthy volunteers

Inclusion criteria

aortic valve stenosis -

Exclusion criteria

familial hypercholesterolemia. \-

Countries

Germany

Contacts

Primary ContactOliver Weingartner, M.D.

oweingartner@aol.com0049-(0)68411623372

Backup ContactUlrich Laufs, M.D.

ulrich@laufs.com0049-(0)68411623372

Outcome results