Fibromyalgia, Irritable Bowel Syndrome
Conditions
Keywords
Experimental study, chronic pain, operant learning, comorbidity, stress, Fibromyalgia w visceral hypersensitivity, Fibromyalgia w/o visceral hypersensitivity
Brief summary
The project investigates on the role of pain avoidance, comorbidity and stress response for the development of chronic somatic and visceral pain. We, the researchers at University Hospital Mannheim, assume that implicit operant learning of pain sensitization is a central mechanism of the process of pain becoming chronic, which is augmented by fear and by avoidance behaviour. Somatic and psychological comorbidity as well as stress factors are further promoting factors in chronic pain development.
Detailed description
Study 1: Implicit operant learning of sensitization and habituation in an experimental heat pain model will be investigated and compared in healthy controls, chronic pain patients with fibromyalgia, with and w/o visceral pain. Study 2: Functional imaging of implicit operant learning of sensitization and habituation in an experimental heat pain model (same subgroups as in study 1).
Interventions
BEHAVIORALExperimental heat pain model
Sponsors
German Research Foundation
Universitätsmedizin Mannheim
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
SINGLE
Eligibility
Sex/Gender
ALL
Age
20 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* Fibromyalgia according to American College of Rheumatology (ACR) criteria * Visceral hypersensitivity according to ROME criteria * Chronic pain according to International Association for the Study of Pain (IASP) criteria
Exclusion criteria
* Abnormal quantitative sensory testing * Psychiatric or neurological anamnesis, except fear and depression * Acute major depression * Substance abuse
Countries
Germany
Contacts
Primary ContactUlrike Kiessling, Dr. phil.
Outcome results
None listed