Perioperative Epidural Trial (POET) Pilot Study

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00221260

Enrollment

250

Registered

2005-09-22

Start date

2005-09-30

Completion date

2008-01-31

Last updated

2008-09-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post Operative Pain Control

Keywords

Analgesia, anesthesia

Brief summary

To investigate if the use of perioperative neuraxial blockade reduces post-operative mortality and cardiorespiratory events compared to intraoperative general anesthesia AND postoperative IV narcotic analgesia. This is a feasibility study to determine if recruitment and execution of the protocol could be done in a timely manner in a much larger trial

Interventions

PROCEDUREanesthesia

Intraoperative general anesthesia AND postoperative IV narcotic analgesia.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

45 Years to No maximum

Healthy volunteers

Inclusion criteria

Subjects at high risk of cardio-respiratory complications post operatively.

Exclusion criteria

Contraindication to epidural anesthesia

Design outcomes

Primary

Measure	Time frame
Combined mortality, MI, cardiac arrest, post operative pneumonia , and respiratory failure	—

Secondary

Measure	Time frame
DVT, pulmonary embolism, TIA, CVA, CHF, clinically significant bradycardia/hypotension	—

Countries

Canada

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026