Effect of Reduction of Inflammatory Status on Glucose Metabolism in Overweight Men

Relation Between Reduction of the Inflammatory Status and Glucose Metabolism in Healthy Overweight Men

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00221052

Enrollment

Registered

2005-09-22

Start date

2005-06-30

Completion date

2005-07-31

Last updated

2006-10-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Inflammation, Obesity, Overweight

Brief summary

Overweight increases the risk to develop chronic diseases including type-2 diabetes and cardiovascular disease. The low-grade inflammatory status often seen in overweight subjects is thought to play an important role in disease development. The purpose of this study is to determine the role of inflammation on glucose metabolism and insulin resistance. In this study the effect of the anti-inflammatory treatment diclofenac on markers of inflammation and on parameters of glucose metabolism will be studied.

Interventions

DRUGDiclofenac

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Masking

DOUBLE

Eligibility

Sex/Gender

MALE

Age

18 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

* Body Mass Index (BMI): 25.1 - 32.0 kg/m2 * Normal Dutch eating habits

Exclusion criteria

* diabetes, cardiovascular disease or hypertension * Not suitable to receive diclofenac treatment * Smoking * Extreme physical activity (more than 6 hours/week) * Reported slimming or medically prescribed diet

Countries

Netherlands

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Apr 1, 2026