Depression
Conditions
Brief summary
Subjects received rTMS daily on 10 consecutive weekdays (five sessions per week), during 20 minutes per session.During the rTMS session, the coil was centered flat over the right parietal cortex. We follow the patient during 12 weeks after the 2 weeks of tms (follow-up period) to measure the depression with different rating scales. We hypothesized that rTMS has a positive effect in the treatment of depression
Interventions
DEVICETranscranial magnetic stimulation
Sponsors
St. Lucas Andreas Ziekenhuis Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE
Eligibility
Sex/Gender
ALL
Age
16 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* In and outpatients aged between 16 and 65 who met DSM-IV criteria for major depressive episode, and who had a score of 25 or higher on the 10-item Montgomery Asberg Depression Rating Scale (MADRS) were included
Exclusion criteria
* A history of epilepsy and any other medical disorder that should preclude the administration of rTMS. Only SSRI's, Mirtazapine and Promethazine as psychotropic medication was accepted if the dosage of antidepressive medication had not been changed for 6 weeks, and if the dosage of Promethazine had not been changed for 2 weeks prior to inclusion. Antidepressive medication had to remain stable during the 14 weeks of the study. Furthermore: schizophrenic disorder, a piece if metal in the brain, pacemaker and left-handed patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To determine the depression (and so the effect of the treatment)we use the 10-item Montgomery Asberg Depression Rating Scale (MADRS)and we measure before tms (T=0), at week 1 (T=1), at week 2 (T=2), at week 4 (T=3), at week 8 (T=4), at week 14 (T=5) | — |
| Besides the MADRS we use the BDI (Beck depression Inventory, the Hamillton deppression and anxiety scale) | — |
Secondary
| Measure | Time frame |
|---|---|
| -.changes in the emotioneal attention, in the emotional memory en in de emotional recognition. | — |
| -.Biochemical changes | — |
| -Changes in anxiety | — |
| >> measured before tms and after (at T=0 and T=2) | — |
| -.Changes in the EEG | — |
| -.Autonomic changes | — |
Countries
Netherlands
Contacts
Primary ContactJudith van der Riet, Drs.
Outcome results
None listed