Clinical and Molecular Characterization of Familial Microsatellite Stable Colorectal Cancer

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00220246

Enrollment

130

Registered

2005-09-22

Start date

2004-03-31

Completion date

2008-09-30

Last updated

2007-03-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colorectal Neoplasms

Keywords

Hereditary colorectal cancer, Microsatellite instability, Chromosomal instability

Brief summary

Two major genetic pathways leading to colorectal carcinoma can well be distinguished; the 'suppressor pathway', which is characterized by inactivation of tumor-suppressor genes and the 'mutator pathway', which is characterized by microsatellite instability. The purpose of this study is to explore a third putative pathway; microsatellite and chromosome stable colorectal cancer where an alternative cancer-causative mechanism might play a role.

Detailed description

Patients with familial colorectal cancer will be characterized with respect to family history, medical history and demographic characteristics. The histopathology of the tumors will be reviewed. Tumor specimens will be analysed on molecular defects.

Interventions

None listed

Study design

Observational model

DEFINED_POPULATION

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

No minimum to 51 Years

Healthy volunteers

Inclusion criteria

\- Colorectal cancer before the age of 51 years Microsatellite stable tumor

Exclusion criteria

Countries

Netherlands

Outcome results