Oesophageal Cancer
Conditions
Brief summary
Knowledge of the impact of gene expression profiling could allow optimisation of chemotherapy regimens for individual patients. It could ensure that patients do not receive a particular form of chemotherapy if it is unlikely to benefit them, and in these circumstances an alternative form of chemotherapy that may prove beneficial could be selected. This information will therefore allow chemotherapy to be tailored to the individual tumour. It may help identify those patients with a poorer prognosis who could be selected for further therapy post surgery or a different treatment strategy at the outset.
Interventions
PROCEDUREEndoscopy
Sponsors
Royal Marsden NHS Foundation Trust
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Any patient with histologically proven operable ,locally advanced and metastatic oesophageal or gastric carcinoma.
Exclusion criteria
* Second malignancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To determine whether specific gene expression profiles are associated with response in oesophago-gastric cancer. | — |
Secondary
| Measure | Time frame |
|---|---|
| Evaluation of the association of gene expression profiling and progression free survival and overall survival in patients with oesophago-gastric cancer. | — |
Countries
United Kingdom
Contacts
Primary ContactSheela Rao
Backup ContactNaureen Starling
Outcome results
None listed