Head Trauma,Closed, Post-Traumatic Headache, Retention Disorders,Cognitive
Conditions
Keywords
Post, Traumatic, Headache, Cognitive
Brief summary
Most patients with CPTH present with additional major cognitive, behavioral and somatic problems. Most drugs used currently have a negative influence on cognition. Therefore, treatment strategies addressing both the headache and cognitive disturbances in patients with CPTH are necessary. (CPTH; Chronic Post Traumatic Headache).
Detailed description
Headache is the most common symptom after a closed head injury, persisting for more then 2 months in 60% of the patients. CPTH is an important cause of consultations in neurology offices and headache clinics, posing a severe burden and affecting the quality of life of sufferers.
Interventions
DRUGGalantamine
Sponsors
Ortho-McNeil Neurologics, Inc.
Rapoport, Alan, M.D.
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
Age range 18-75 CPTH according to ICHD-2 Fertile woman using adequate birth control Willing and able to give informed consent Willing and able to complete the entire course of the study to comply with study instructions Stable does of preventive medication \-
Exclusion criteria
Subject is pregnant or lactating Significant medical or psychiatric disease Previous failure to 4 or more adequate trials of preventive medication Patient on non-stable dose of medication used to prevent CPTH \-
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary Headache Efficacy Measure; number of pain free days after 3 months | — |
Secondary
| Measure | Time frame |
|---|---|
| Consumption of rescue medication | — |
| Number of days with moderate or severe headache after 3 months. | — |
Countries
United States
Contacts
Primary ContactLori L Flanagan, RN
Backup ContactKathy Diomede, RN
Outcome results
None listed