Mechano-physiological Approach to Anorectal Function

Mechano-physiological Approach to Normal Anorectal Function and the Classification of Defecatory Disorders

Status

Terminated

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00219518

Enrollment

Registered

2005-09-22

Start date

2006-02-28

Completion date

2011-05-31

Last updated

2018-05-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Constipation

Keywords

Defecography, Pelvic floor dyssynergia, Anismus

Brief summary

We hypothesize that defecatory disorders can be described in mechanical terms which would allow a mechanistic description of disorders which would in turn allow better directed biofeedback mechanisms to treat disorders of defecation.

Detailed description

Disorders of defecation are very common and the process of defecation remains poorly described. This results in a limited approach to treatment of patients, with limited success. This study will simultaneously measure multiple components of the process of defecation - the abdominal wall and perineal muscle activity, the pressure within the rectum and in the anal canal and the change in shape of the anorectal region of the colon, in order to develop a biomechanical model which can describe the normal and abnormal defecatory process. It is anticipated that, by understanding the process in these terms will allow a new approach to categorizing and describing defecation problems which in turn will lead to more specific approaches of treatment which will be tailored to individual patients. These parameters will compared in volunteers with no defecatory disorders and patients with defecatory disorders who are being referred for defecography as part of their clinical evaluation.

Interventions

PROCEDUREdefecography

insertion of catheter to record pressure. Insertion of barium to outline rectum and fluoroscopy to define change in rectal contour and expulsion of barium during the study.

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

Controls Inclusion Criteria: * Women * No defecatory problems * On no medication which affect bowel habits

Exclusion criteria

* Pregnancy Patients Inclusion Criteria: * Difficulty in defecation * Women

Design outcomes

Primary

Measure	Time frame	Description
change in shape of anorectum during changes in intraabdominal pressure and defecation	start of anorectal manometry procedure until procedure end	measure change in dimension over time

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026