Angina, Coronary Artery Disease
Conditions
Keywords
Aerobic capacity, Exercise training, CABG, Endothelial function
Brief summary
The aim is to evaluate the effect of exercise training upon endothelial function in the mammary artery of patients who are scheduled for CABG, as well as study the functional properties of single cells isolated from a small biopsy of the left ventricle obtained during surgery.
Interventions
BEHAVIORALExercise training
Intensity controlled exercise training before the scheduled bypass surgery
Sponsors
Norwegian University of Science and Technology
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
* Scheduled for CABG both with and without heart failure
Exclusion criteria
* Unstable angina * Unable to walk on a treadmill (except those with heart failure who only will serve as a reference group) * Participation in another study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cardiovascular function and quality of life | Before and up to 1 year after intervention |
Secondary
| Measure | Time frame |
|---|---|
| Structure and function of cardiomyocytes | After the intervention period |
| Cardiomyocyte structure and function | after the intervention period |
Countries
Norway
Outcome results
None listed