Evoked Fields After Median and Ulnar Stimulation

Evoked (Magnetic) Cortical Fields for the Comparative Study of Mechanisms Underlying Chronic Non-malignant Pain in Peripheral Nerve Injury (CRPS II) and CRPS I (Chronic Regional Pain Syndrome I)

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00217243

Enrollment

Registered

2005-09-22

Start date

2005-06-30

Completion date

2007-06-30

Last updated

2009-09-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Complex Regional Pain Syndromes

Keywords

Pain, Magnetoencephalography, Median, Ulnar, Causalgia, Complex regional pain syndrome, Evoked fields, Nerve injury, Neuropathic pain

Brief summary

In order to be able to study the effects of evoked fields with magnetoencephalography (MEG) in two groups of patients, comparison is made with a group of healthy volunteers.

Detailed description

This study is directed at the (central and / or peripheral) mechanisms of pain and the cortical changes (plasticity) due to chronic non-malignant pain in two groups of patients and one healthy volunteer group. The aim of the study is further to evaluate cortical processes by MEG (and fMRI, if feasible) to quantify and qualify the responses, localise the generators and study the effects of a pain therapy. To search for patterns that may result in diagnostic criteria and have an indicative value for the treatment and the monitoring of the effects. Finally the study not only intends to support clinical diagnosis but also to provide tools to monitor treatment and support the choice (algorithm) between SCS and SAN. An algorithm, facilitating decision making between these two treatments, will be promoted. It should also provide a clinical decision tool for the use of SAN

Interventions

OTHEREvoked fields before and after a local block (Xylocaine)

MEG registration after electrical median and ulnar nerve stimulation in subjects and patients. In the patient group another MEG was performed after an anaesthetic block (1-2 ml Lidocaine 1%) at the site of the nerve injury producing a painfree state

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

17 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

CRPS I: * (Absolute) functio laesa, secondary pain and cold sensations * (Relative) abnormal skin colour, allodynia, hyperalgesia, hyperpathia, hyperhydrosis,oedema, increased nail growth, increased hair growth. (At least 4 need to be present). CRPS II: * All the previous but evidence of traumatic peripheral nerve injury.

Exclusion criteria

* General condition * Pregnancy * Technical implants (pacemaker, SCS: disturbs MEG)

Countries

Netherlands

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026