Healthy Volunteers
Conditions
Brief summary
This study is being done to learn if yohimbine, a naturally occurring drug, affects the speed at which food travels through the stomach, intestines and colon, and if yohimbine affects the amount of liquid you can drink in a short period of time. Understanding how yohimbine works on the gut may help develop new treatments for patients with constipation. Yohimbine has been approved by the Food and Drug Administration (FDA) for routine clinical use, however, its use as proposed in this study is considered investigational.
Interventions
DRUGYohimbine, oral
Sponsors
National Institutes of Health (NIH)
Mayo Clinic
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Healthy male or non-pregnant, non-breastfeeding female volunteers, -18-65 years old; * Able to provide written informed consent before participating in the study; * Able to communicate adequately with the investigator and to comply with the requirements for the entire study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Colonic transit | — |
Secondary
| Measure | Time frame |
|---|---|
| Small bowel transit time | — |
| Gastric emptying time | — |
| Maximum tolerated volume ingested during satiation testing | — |
| Average stools per day | — |
| Stool consistency | — |
Countries
United States
Outcome results
None listed