Dermatitis, Psoriasis
Conditions
Brief summary
Hand and foot skin diseases, such as dermatitis and psoriasis, that do not respond to topical creams can be treated with ultraviolet light therapy. Topical psoralen plus ultraviolet A (PUVA) is commonly used to treat these conditions, but requires additional time for the hands and feet to soak in psoralens before the light treatment. Newer narrowband ultraviolet B (NBUVB) units have become available which allow for light treatment without soaking first. The purpose of this study is to determine if NBUVB is as effective as PUVA for hand and foot skin diseases.
Interventions
PROCEDURENarrowband Ultraviolet B (TL-01UVB) Therapy
PROCEDURETopical Psoralen plus ultraviolet A (PUVA)
Sponsors
Mayo Clinic
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Bilateral hand or foot skin disease (dermatitis, psoriasis, etc.) with symmetric distribution and severity.
Exclusion criteria
Age \<18 years Pregnancy Liver disease Kidney disease History of skin cancer Phototherapy or systemic therapy for the skin condition in the preceding 3 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of treatments required to reach clearance | Baseline to 15 months |
Secondary
| Measure | Time frame |
|---|---|
| Change in global score | Baseline to 15 months |
| Number of patients reaching clearance | Baseline to 15 months |
| Change in symptom score (erythema, scaling/hyperkeratosis, papular/vesicular eruption, and fissures) | Baseline to 15 months |
| Adverse effects | Baseline to 15 months |
| Number of days in remission | Baseline to 15 months |
Countries
United States
Outcome results
None listed