Abdominal Pains, Lymphoedema, Mansonelliasis, Pruritus
Conditions
Keywords
Mansonella perstans, microfilaraemia, ivermectin, albendazole, Uganda
Brief summary
Mansonella perstans (M. perstans) infection is widespread in Uganda. Knowledge about the epidemiology of this infection, and of the morbidity it induces is poor, and no effective treatment is available. The study aims at providing data on diagnostic, epidemiological, morbidity and treatment aspects of M. perstans infections in Uganda.
Detailed description
Overall objective: to investigate diagnostic, epidemiological and treatment aspects of M. perstans in Uganda with relevance to control Specific objectives: 1. To establish the pattern of diurnal periodicity of M. perstans microfilaraemia in humans 2. To establish the patterns of M. perstans microfilaraemia and possible clinical manifestations related to this infection in two communities with medium to high endemicity 3. To determine the efficacy of ivermectin alone and the combination of ivermectin and albendazole on M. perstans microfilaraemia.
Interventions
DRUGivermectin and albendazole
Sponsors
Ministry of Health, Uganda
DBL -Institute for Health Research and Development
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
DOUBLE
Eligibility
Sex/Gender
ALL
Age
5 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Individuals \>= 5 years with or without M. perstans infection
Exclusion criteria
* Individuals \< 5 years * Pregnant women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| microfilariae periodicity patterns | — |
| epidemiology of M. perstans at community level | — |
| clinical spectre among infected | — |
| reduction in microfilaraemia | — |
Secondary
| Measure | Time frame |
|---|---|
| treatment effect on clinical manifestations | — |
Countries
Uganda
Outcome results
None listed