Radiotherapy
Conditions
Keywords
patient who will undergo definitive radiotherapy
Brief summary
The purpose of this study is to compare the baseline incidence of variant alleles in the ATM and/or other DNA repair genes present in the Native American population versus the non-Native American population. It is thought that a higher baseline incidence of the variant alleles in the ATM gene may correlate to higher rates and higher grades of radiation toxicities noted in the Native American population.
Interventions
None listed
Sponsors
University of Wisconsin, Madison
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
MALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Indication for radiotherapy. * Ability or desire to donate a blood sample and be followed closely for radiation toxicities
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| to determine baseline incidence of variant alleles in ATM | one blood draw | to determine the baseline incidence of variant alleles in ATM resent in the population of Native americans with cancer who are undergoing radiation therapy to a similar group of non-native americans who have undergone or are undergoing raditohterapy |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| to compare the baseline incidence of variant alleles in ATM | one blood draw | to compare the baseline incidence of variant alleles in ATM resent in the population of Native americans with cancer who are undergoing radiation therapy to a similar group of non-native americans who have undergone or are undergoing raditohterapy |
Countries
United States
Outcome results
None listed