L-arginine Supplementation and Exercise; L-arginine Supplementation and Renal Function

Effects of Oral Chronic L-arginine Supplementation on Exercise and Renal Function of Heart Transplant Recipients

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00213915

Enrollment

Registered

2005-09-21

Start date

2004-02-29

Completion date

2004-12-31

Last updated

2025-12-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart Transplantation

Keywords

L-arginine, exercise capacity, renal function, nitric oxide, exercise capacity using a maximal exercise test, urinary elimination of a saline load using blood and urinary samples

Brief summary

* exercise capacities are still altered after heart transplantation partly due to peripheral endothelial dysfunction * cyclosporin-induced renal dysfunction may be due to renal endothelial dysfunction and can be reversed in an animal model by L-arginine supplementation * to determine the potential beneficial effect of L-arginine supplementation on exercise capacity and renal function of heart transplant recipients

Interventions

DRUG12 g of L-arginine glutamate during 6 weeks twice a day

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Male (\> 18 years old) stable heart transplant recipient for at least 6 weeks * Stable treatment for at least 3 months * Sedentary people

Exclusion criteria

* Unstable cardiac pathology * Obesity (IMC \> 40) * Participation in another study in the last month * Chronic renal failure (creatinine clearance \< 20 ml/min) * Renal transplantation * Diabetes * Impossibility to practice exercise test * Nitrate therapy

Design outcomes

Primary

Measure	Time frame
Maximal and sub maximal exercise capacity at the end of the 6 weeks L-arginine supplementation. Renal function at the end of the 6 weeks	—

Secondary

Measure	Time frame
No secondary effects	—

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026