TWIST Human Gene and Cleft Lips and Palates

Status

Terminated

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00213889

Enrollment

Registered

2005-09-21

Start date

2003-02-28

Completion date

2008-07-31

Last updated

2015-03-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cleft Lip

Keywords

Facial clefting, twist, craniofacial development genes, Human cleft lip and palate, cleft lip and palate

Brief summary

This study uses a sequence analysis for TWIST and other craniofacial development genes, among patients presenting with facial clefting.

Interventions

OTHERNone: molecular genetics diagnosis procedure only

None: molecular genetics diagnosis procedure only

Study design

Allocation

NON_RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

1 Months to No maximum

Healthy volunteers

Inclusion criteria

Patients aged from 1 month to 18 years: * Parents agree to enrollment or patients, themselves, agree to enrollment when able to do so * Healthcare insurance holders * Display facial clefting Grown patients over 18 years of age: * Agree to enrollment * Display facial clefting * Healthcare insurance holders

Exclusion criteria

* Patients declining enrollment * Patients without healthcare insurance

Design outcomes

Primary

Measure	Time frame
to show, among patients displaying facial clefting, the TWIST mutations and the mutation in genes involved with TWIST in craniofacial development	Not relevant

Secondary

Measure	Time frame
to show, among patients displaying facial clefting and mutations in such genes, possible mutations in the same genes	Not relevant

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026