Evaluation of Myocardial Viability by Means of Low-dose Dobutamine Gated SPECT (the DOGS Study)

Prediction of Left Ventricular Function Changes Using Low Dose Dobutamine Gated SPECT in Patients Referred for Viability Assessment: The DOGS (DObutamine Gated Spect)Study.

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00213746

Enrollment

Registered

2005-09-21

Start date

2003-10-31

Completion date

2005-12-31

Last updated

2013-06-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Arteriosclerosis, Heart Failure, Congestive, Myocardial Infarction, Myocardial Ischemia, Myocardial Stunning

Keywords

Coronary Arteriosclerosis, Heart Failure, Congestive, Myocardial Infarction, Myocardial Revascularization, Tomography, Emission-Computed, Single-Photon, Dobutamine, Myocardial Stunning, Myocardial Hibernation

Brief summary

Viability assessment remains a clinical challenge in patient with coronary artery disease and left ventricular dysfunction. Several imaging modalities are available for evaluating myocardial viability, based either on perfusion or on contractile reserve analysis. Briefly, perfusion analysis is highly sensitive and contractile reserve highly specific. A combined analysis of both perfusion and contractile reserve has been proposed to improve the diagnostic accuracy in patient referred for a revascularization procedure. However, the value of this combined analysis has not been validated in unselected patients referred for viability assessment. The patients enrolled in the study will undergo a nitrate enhanced rest gated SPECT using a Tc-99m labeled tracer (sestamibi or tetrofosmine) followed by a second gated SPECT acquired during a low-dose dobutamine infusion (10 mcg/kg/mn). All patients will have a 6-month clinical and imaging follow-up, including physical examination and a nitrate enhanced rest gated SPECT using the same radiopharmaceutical. All treatments received during this 6-month period will be recorded, including medical therapy and coronary revascularization (angioplasty, stenting and CABG). Finally, the value of baseline perfusion and contractile reserve analysis in predicting left ventricular ejection fraction changes at 6-month follow-up will be evaluated.

Interventions

None listed

Study design

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* Documented coronary artery disease * Left ventricular dysfunction (LVEF \< 50%) * Patients referred to the Nuclear Medicine department for myocardial viability assessment * Sinus Rhythm * Acceptance of a 6-month follow-up * Signed informed consent

Exclusion criteria

* Recent acute coronary syndrome (\< 21 days) * Atrial Fibrillation or significant arrhythmias * Implanted pacemaker * Contra indication to dobutamine * Non ischaemic cardiomyopathy * Pregnancy

Countries

Belgium, France

Outcome results