Severe Acute Cardiogenic Pulmonary Edema
Conditions
Keywords
Pulmonary edema, respiratory failure, pressure support ventilation, continuous positive pressure
Brief summary
To evaluate whether bilevel positive airway pressure more rapidly improves ventilation than continuous positive airway pressure (CPAP) in patients with acute pulmonary edema. CPAP is delivered via a simple device connected to oxygen.
Interventions
DEVICEBoussignac CPAP - bilevel ventilation support
Sponsors
University Hospital, Rouen
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
16 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* age \> 16 yrs, acute onset of severe respiratory distress, bilateral rales and typical findings of congestion on chest radiograph * breathing frequency of \> 30/min, SpO2 \>90%, use of accessory respiratory muscles
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement in PaCO2 at the end of ventilation | — |
Secondary
| Measure | Time frame |
|---|---|
| Endotracheal intubation, myocardial infarction and mortality during the first 24 hours | — |
| Duration of the ventilation | — |
| Blood gases, vital signs | — |
| Time to transfer to medical ward | — |
| Time to hospital discharge | — |
| Easiness to use was evaluated by nurses | — |
| Patients operational tolerance | — |
| Complications of each ventilation mode | — |
Countries
France
Contacts
PRINCIPAL_INVESTIGATORFabienne MORITZ, MD
University Hospital, Rouen
Outcome results
None listed