myoARRAY and TcLandscape Analysis for the Diagnosis of Inflammatory Myopathies

Transcriptome Analysis Through a Dedicated Macro-array and TcLandscape Repertoire Analysis for Diagnosis of Myositis.

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00213629

Acronym

MYOARRAY

Enrollment

100

Registered

2005-09-21

Start date

2004-11-30

Completion date

2010-07-31

Last updated

2012-02-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Polymyositis, Dermatomyositis

Keywords

myositis, cDNA arrays, Genes, T-Cell Receptor beta

Brief summary

The diagnosis of the different forms of inflammatory myopathies (polymyositis, dermatomyositis, inclusion-body myositis...) remains difficult which may lead to unappropriate patient care. Objective 1 : to develop and evaluate the diagnostic value of a dedicated DNA-array (myoARRAY) for adult-onset muscular diseases with focus on inflammatory myopathies. Objective 2 : to evaluate the diagnostic value of T cell repertoire (TcLand) analysis to distinguish different forms of inflammatory myopathies.

Interventions

OTHERT cell repertoire analysis

blood T cell repertoire analysis

OTHERtranscriptome analysis

transcriptome analysis from muscle biopsy

Study design

Allocation

NON_RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 76 Years

Healthy volunteers

Inclusion criteria

* indication of muscle biopsy for diagnostic purpose * written informed consent

Exclusion criteria

* vasculitis * coagulation disorder, impossibility to perform muscle biopsy

Design outcomes

Primary

Measure	Time frame
transcriptome	at inclusion

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026