Healthy Volunteers
Conditions
Brief summary
Gut barrier plays a major role in defence of the organism. During catabolic states, like major surgery or inflammation, gut barrier could be altered. It has been reported that preoperative nutritional support may have beneficial effects on clinical outcome in patients with surgery on gastrointestinal tract. Glutamine, which is a conditionally essential amino, have been reported to modulate inflammatory, antioxidant responses and protein metabolism in intestine. In addition, glutamine supply improves clinical outcome in critically ill patients. Antioxidant micronutrients may also have some beneficial effects in intestine by improving antioxidant response and might also regulate protein expression. Nevertheless, effects of glutamine combined to antioxidant micronutrients have not been evaluated. Thus, the aim of this study will be to assess the influence of glutamine and glutamine-antioxidant micronutrients-containing solutions on intestinal response in humans.
Interventions
DRUGGlutamine
DRUGGlucose
DRUGglutamine-antioxidants containing solution
Sponsors
University Hospital, Rouen
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy volunteers, male and female, aged between 18 and 50 years, negatives for HIV1, 2 and for HVC and HVB * BMI between 20 and 24 kg/m², * giving their written informed consent * no-smokers * no allergic and digestive antecedents
Exclusion criteria
* smokers * Allergic and digestive antecedents, * pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Impact on protein synthesis rate and proteolytic activities in intestine. | at the end of infusion (hour 5) |
Secondary
| Measure | Time frame |
|---|---|
| Comparison of protein expression pattern and glutathione synthesis. | at the end of infusion (hour 5) |
Countries
France
Outcome results
None listed