Scleroderma
Conditions
Brief summary
Scleroderma is an autoimmune disease of unknown origin. Recently, the role of environmental factors, and particularly toxic drug exposure, in the genesis of scleroderma has been suggested. This prompted us to conduct this prospective, case-control, multicentric study, including 2 groups of subjects: * 100 patients with scleroderma * 300 sex- and age-matched healthy controls. The aim of our study is to determine whether exposure to toxics is higher in patients with scleroderma compared with healthy controls.
Detailed description
The data of patients with scleroderma and healthy controls will be compared regarding: * a standardized questionnaire about cursus laboris at initial inclusion * a search for toxics in blood, urine and hair: at initial exvaluation, 6 month and 2 year-follow-up
Interventions
OTHERQuestionnary for environmental factors research
Questionnary for environmental factors research
Sponsors
University Hospital, Rouen
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 76 Years
Healthy volunteers
Yes
Inclusion criteria
* patients with scleroderma with: * age range : 18 to 76 years * written consent
Exclusion criteria
* patients with other connective-tissue disorders * pregnant women * patients with psychiatric conditions * unwritten consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Identification of environmental factor | Day 1 |
Countries
France
Outcome results
None listed