OPALS Critical Care Sub-Studies

Ontario Prehospital Advanced Life Support (OPALS) Study Phase III Cardiac Arrest and Critical Care Sub-Studies - Chest Pain Sub-Study, Respiratory Sub-Study, and Major Trauma Sub-Study

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00212953

Enrollment

21000

Registered

2005-09-21

Start date

1997-03-31

Completion date

1999-05-31

Last updated

2010-10-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiac Arrest

Keywords

Chest Pain,, Shortness of breath,, Injury,, Trauma

Brief summary

The purpose of the study is to evaluate the incremental benefit of a full advanced life support EMS program on the outcomes of chest pain, respiratory and major trauma patients.

Interventions

PROCEDUREAdvanced Life Support

Study design

Allocation

NON_RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

PREVENTION

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

16 Years to No maximum

Healthy volunteers

Inclusion criteria

* Chest Pain Sub-Study: Adult patients with a complaint of chest pain of an acute nature transported to hospital by ambulance. Patients with a complaint of pain in arms, neck or jaw if consistent with myocardial ischemia. Patients must have an ambulance return code of prompt, urgent, or no patient carried. * Respiratory Sub-Study: Adult patients with a chief complaint of shortness of breath defined as ACR codes of Respiratory Failure, Shortness of Breath NYD, Pulmonary Edema (CHF), Asthma and had either prehospital assisted ventilation or abnormal respiratory rates (>=24 or <=10) * Major Trauma Sub-Study: Adult patients who have suffered an injury from any mechanism with an Injury Severity Score of >12 who have been transported to hospital by land ambulance, and who have been entered into the Ontario Trauma Registry (OTR) Comprehensive Data Set.

Exclusion criteria

* All Sub-Studies: * Patients under the age of 16 * Patients who are vital signs absent prior to EMS arrival. * Chest Pain Sub-Study: * Patients suffering primarily from respiratory distress, respiratory failure, pulmonary edema, asthma, palpitations or epigastric pain. pain

Design outcomes

Primary

Measure	Time frame
Survival to discharge	—

Secondary

Measure	Time frame
Disease Specific Quality of Life CPC Score and FIM Score	—
Performance of ALS Procedures	—
Response Time Intervals	—
Generic Quality of Life	—
Length of Stay in Critical Care Units	—
Ventilator time	—
Disease Specific Quality of Life	—
Length of Stay in Hospital	—

Countries

Canada

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026