A Pilot Study of the Neural Correlates of Treatment Effect on Nicotine Craving

Nicotine Craving: Neural Correlates of Treatment Effect - A Pilot Study

Status

Completed

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00208858

Enrollment

Unknown

Registered

2005-09-21

Start date

2004-12-31

Completion date

2006-12-31

Last updated

2014-06-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Tobacco Use Disorder

Brief summary

The purpose of this study is to gather pilot data to determine feasibility of and guide the development of a larger clinical trial investigating the effects of topiramate as an adjunct to nicotine replacement therapy and behavioral counseling in smoking cessation treatment. It is hypothesized that topiramate will decrease nicotine craving and result in improved outcomes for smoking cessation.

Interventions

DRUGTopiramate

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Masking

DOUBLE

Eligibility

Sex/Gender

MALE

Age

18 Years to 55 Years

Inclusion criteria

* Male, between ages of 18-55 * Meets DSM-IV criteria for nicotine dependence * Smoke at least 20 cigarettes per day * Motivated to quit smoking

Exclusion criteria

* Serious or unstable medical conditions * Current psychiatric disorder requiring medication or treatment * Taking medication that create risk of interaction with study drug * Current participation in another smoking cessation treatment

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026