Dosage Effects of Folic Acid on Blood Folates of Honduran Women

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00207532

Enrollment

100

Registered

2005-09-21

Start date

2005-03-31

Completion date

2005-06-30

Last updated

2005-09-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Spina Bifida and Anencephaly

Brief summary

CDC staff at the National Center on Birth Defects and Developmental Disabilities have been working closely with a Honduras-based organization, Project Healthy Children (PNS) and the Ministry of Health, on a folic acid supplementation study among female maquila workers. Participants are divided into two groups. One group receives a 1.0 milligram pill daily while the other group receives a 5.0 milligram pill weekly. The aim of this study is to assess serum blood folate levels measured at baseline, midpoint, and endpoint of the study. Hypothesis: Folic acid (5mg)given once weekly is as effective as folic acid (1mg)given daily in raising blood folate levels.

Interventions

DRUGfolic acid

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

DOUBLE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 49 Years

Healthy volunteers

Yes

Inclusion criteria

minimum employment in factory 6 mths \-

Exclusion criteria

* pregnant * currently consuming folic acid * prior birth-defect affected pregnancy * chronic disease * currently taking folic acid antagonist

Countries

Honduras

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026