Does Caffeine Affect the Sensitivity of Adenosine Perfusion Scans?

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00205166

Enrollment

Registered

2005-09-20

Start date

1999-06-30

Completion date

2004-12-31

Last updated

2012-10-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Artery Disease

Keywords

adenosine tracer scans, coronary artery disease, caffeine

Brief summary

We are studying the affect of caffeine on the sensitivity of detecting coronary artery disease (blockages in the blood flow to the heart) with adenosine tracer scans. Adenosine is a drug used routinely in patients to relax heart blood vessels in order to assess for the presence of coronary artery disease. Often, if patients have had caffeine, the adenosine scan is not used because of the belief that caffeine may reduce the ability to detect coronary artery disease. We would like to test whether caffeine affects our ability to detect coronary artery disease with adenosine tracer scanning. We will perform an imaging study of the heart with adenosine after you have received caffeine.

Interventions

PROCEDURECardiac SPECT imaging Rest and Stress

adenosine perfusion scintigraphy

DRUGCaffeine

Caffeine 400 mg po

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* Patients who have already completed rest/stress 99mTc sestamibi or 99mTc tetrofosmin imaging will be given a form describing this protocol and asked to volunteer for the additional scan

Exclusion criteria

* history of asthma, bronchospastic COPD, or renal failure

Design outcomes

Primary

Measure	Time frame
This protocol has a specific aim of determining whether prior caffeine administration affects the sensitivity and specificity of adenosine perfusion scintigraphy for detection of impaired coronary vascular reserve.	Assessment is made at the time of research adenosine perfusion scintigraphy

Secondary

Measure	Time frame
determination of caffeine levels in patients instructed to hold caffeine prior to adenosine imaging	Assess at time of lab sample results obtained

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026