Healthy Volunteers
Conditions
Keywords
Cardiac PET imaging, Radiopharmaceutical tracers
Brief summary
In this study we are looking at the blood flow to the heart using two different chemical tags or tracers that give off a low level of radiation. The tracers used in this study are called O15-water and F17-fluoromethane. These tracers mix with the blood and will move through the body. The researchers will use positron emission tomography (PET scans)to track the tracers as they moe through the heart and chest.
Interventions
PROCEDURECardiac PET imaging- rest and pharmacological stress
Sponsors
University of Wisconsin, Madison
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* 1\. Age 18 to 40 years old 2. Willing to provide written informed consent
Exclusion criteria
* 1\. A history of CAD 2. A history of active bronchospasm or asthma on theophylline bronchodilators 3. A history of any cardiac risk factors including: HTN, Diabetes, Hyperlipidemia, Smoking, and premature CAD in immediate family member 4. A history of liver disease or other significant disease 5. Females who are pregnant or lactating
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| -- implement myocardial perfusion quantification for O15-labeled water at rest and with pharmacologic stress, | assess at time of PET scan |
| -- determine the biodistribution of fluoromethane in the thorax to see if it is usable for a cardiac perfusion tracer, | assess at time of PET Scan |
Secondary
| Measure | Time frame |
|---|---|
| --develop initial methods for quantification of myocardial perfusion if applicable for labeled fluoromethane. | assess at time of PET scan |
Countries
United States
Outcome results
None listed