Bone Marrow Transplantation, Hematopoietic Stem Cell Transplantion
Conditions
Keywords
bone marrow transplant (BMT), hematopoietic stem cell transplant (HSCT)
Brief summary
Nutrition is an important part of the recovery process after having a head injury so that subjects can gain strength and fight off infection. Liquid nutrition formulas are often given to patients through a tube that has been placed into the intestines for feeding when they are unable to eat on their own. Some reports suggest that nutrition with extra amounts of the amino acid called glutamine may decrease infections and hospital stay in severely injured patients. The purpose of this study is to evaluate if giving extra amounts of an amino acid called glutamine with liquid nutrition formulas will decrease the risk of infection and length of stay in the intensive care unit after having a head injury.
Interventions
DRUGnutritional supplement
DRUGglutamine popsicle
Sponsors
University of Wisconsin, Madison
Study design
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
PREVENTION
Masking
DOUBLE
Eligibility
Sex/Gender
ALL
Age
4 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Males * Nonpregnant females * Receiving chemotherapy for BMT/HSCT
Exclusion criteria
* Documented hepatic dysfunction * History of cirrhosis * History of acute renal failure (creatinine clearance \< 25 mL/min) * Gastrointestinal malabsorptive disorder
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| grade of mucositis | — |
Secondary
| Measure | Time frame |
|---|---|
| need for intravenous versus oral nutritional supplementation | — |
Countries
United States
Outcome results
None listed